EEG methods in the study of the mechanisms and site of action of centrally acting drugs.

Our Jaboratory has since long heen associated with neuropharmaco· logical research. Among other methods, the one in which we have heen particulary keen is that of brain electrical activity recording. Looking hack to tbe work we bave performed in these years, l would like to present to you an account of the evolution of our techniques, showing how they bave changed along time (Table l). The first experiments were carried out in the rabbit acute preparation. In this setting we were used to ascertaiD the modificatioDs of the spontaDeous EEG induced by drugs, together with their inft.uence OD the arousal patterns due to the electrical stimulation of tbe reticular formation, oD the recruiting